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The 17-Hydroxyprogesterone (17-OHP) test, also known as the 17-OHP newborn screen, is a blood test done on newborns using a dried blood spot (DBS) sample to screen for congenital adrenal hyperplasia (CAH). This test measures the concentration of 17-hydroxyprogesterone in the blood, which is an important hormone precursor in the adrenal glands. Elevated levels of 17-OHP can indicate CAH, a genetic disorder that can affect the adrenal glands and lead to life-threatening conditions if not detected and treated early.