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17?-Hydroxyprogesterone (17?-OHP), also known as 17-OH progesterone or 17-OHP, is a naturally occurring progestogen steroid hormone that's a crucial intermediate in the synthesis of other steroid hormones like cortisol, aldosterone, and sex hormones. It's primarily produced by the adrenal glands and is used in newborn screening tests to detect congenital adrenal hyperplasia (CAH).