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The 24-hour urinary cortisol/creatinine ratio is a test used to measure cortisol levels in the urine over a 24-hour period, often in conjunction with creatinine measurement. This test is primarily used to diagnose and monitor conditions like Cushing's syndrome, Addison's disease, and other adrenal gland disorders. It helps determine if there's an overproduction or underproduction of cortisol, a hormone produced by the adrenal glands.